Low grade inflammation & chronic disease

how low grade infllammation leads to chronic disease

What is low-grade inflammation?

Low-grade inflammation is a mild inflammation that is hardly detectable in the blood. With a low-grade inflammation, the immune system is continuously slightly activated. It is a body’s strategy to ensure that pathogens can multiply poorly.

The cause of low-grade inflammation

Normally the body is protected against harmful substances and pathogens through body barriers. Examples of these barriers are our skin and intestinal wall. They ensure that all the mess you come in contact with is kept out of your cells. A Western lifestyle with chronic stress, toxins, and unhealthy food ensures that these body barriers become more permeable. They are leaking and are no longer able to stop all harmful substances and pathogens. The result is that anything can leak into the bloodstream, also harmful substances.

When an intestine is highly permeable, often referred to as leaky gut,  bacterial residues from the stools leak into the bloodstream. If these remains contain the wrong pathogenic bacteria, the immune system will be activated. Depending on this person’s health status, a mild or violent immune response will occur.  A violent immune response can cause a lot of damage certainly if you cannot end the response in time. A fierce reaction that cannot be ended leads to death. When you cannot end a violent response in time, your body will choose for a mild immune response. This is the so-called low-grade inflammation. It is an emergency solution that ensures that pathogens can multiply poorly and cause little damage. However, since it is a mild immune response, the pathogens will not be killed.


When the body barriers are leaking for a long time, and there is a constant presence of pathogens in the bloodstream, the immune system remains continuously activated. Chronic inflammation will develop, often accompanied by insulin insensitivity (insulin resistance). In the long term, this leads to vague symptoms such as fatigue, mood swings, difficulty losing weight and sleeping problems. But also to lifestyle diseases such as MS, Crohn, Ulcerative colitis, type 1 and 2 diabetes, Alzheimer’s, Parkinson’s, depression, rheumatoid arthritis, hay fever, asthma, COPD, osteoporosis, arteriosclerosis, high blood pressure, stroke, and heart failure can occur.

Embrace fever

In contrast to low-grade inflammation, fever is a violent immune response. Where low-grade inflammation only causes pathogens to multiply poorly, fever causes pathogens to be killed. Low-grade inflammation is a temporary emergency solution. Fever is a real solution. Low-grade inflammation is ended by developing a fever. It is, therefore, very healthy to get a fever to combat intruders.

You will only receive permission for a violent immune reaction (fever) if you can also end it on time. This depends, among other things, on the amount of omega-3 fatty acids EPA and DHA that you ingest. But also on your vitamin D and magnesium status. People who are deficient in these nutrients will not develop a fever. The result is that low-grade inflammation is never ended. This is often the case with people who are never ill but have chronic symptoms.

As soon as you start to live a healthier life, you may become able to develop a fever again. There is nothing wrong with this. It is healthy. So be happy if you have a fever.

Summary of this subject

Body barriers such as the skin and intestinal wall have the purpose of keeping junk outside the body. A Western lifestyle ensures that the barriers are damaged and leak. The result is that all kinds of harmful substances leak into the bloodstream. This causes an activation of the immune system.

Depending on the situation, a mild or violent immune response takes place. A fierce immune reaction (fever) only occurs when you can end it on time. If you cannot do this, the body uses a temporary emergency solution, namely a mild immune response (low-grade inflammation). This is a strategy to ensure that pathogens are difficult to multiply.

If the body barriers are constantly leaking and the immune system is continuously activated, this eventually leads to complaints and lifestyle diseases. Low-grade inflammation is stopped as soon as a fever occurs. You will only be allowed to develop a fever once you can control this immune response. This requires the omega-3 fatty acids EPA and DHA, magnesium and vitamin D.

As soon as you start to live healthier, you may develop a fever more often. There is nothing wrong with this. It is just very healthy.




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